Melanie MacDonald lives in downtown St. Catharines and is an active member of the Niagara Artists' Centre, the region's only artist-run centre. She has participated in group and solo exhibitions in the Niagara, Toronto, Hamilton, Kingston, and Quebec. In 2008, her work was selected for Carte Blanche 2: Painting a book published by Magenta Publishing for the Arts that features the work of 180 Canadian painters. In 2009 she received a Trillium Excellence in the Arts Award (in the emerging artist category) sponsored by the St. Catharines Culture Committee. She has also received OAC exhibition assistance from the Ontario Arts Council in 2003, 2004, 2007, 2012 and 2013.